Pharmacists: How can I know the rationale behind the contraindications?
Within the contraindications there are different types . Depending on what you look for you can find information in one way or another: Contraindications for side effects: that refer to an unintended consequence that is part of the pharmacological action of a medication; for example, dry mouth in the course of a treatment with anticholinergics. Think of, a patient with s. Sjogren, who sees his symptoms worsened by taking anticholinergics. It could also be a non-selective beta-blocker and an asthmatic patient. The physiological mechanism of bronchial relaxation is through beta2 agonism, if you block it you can trigger asthma attacks. You can usually find the cause by looking at the physiology of the mechanism of action and physiology of the side effect.Also books of clinical pharmacolgy usually explain this.
Secondary effect, on the other hand, is an unintended manifestation that arises as a consequence of the fundamental action of a medicine, but that is not an inherent part of it. By way of example, hypokalemia may occur that occurs in the course of treatment with thiazide diuretics. You can also evaluate it depending on the mechanism of action of the drug. Adverse reaction or undesirable effect, finally, refer to the unwanted effects that, in addition, are harmful. In these the cause of the adverse reaction is not usually known . You know the frequency of appearance, the characteristics of the population that it affects … in these cases the information can be found in pivotal trials, or in safety drug monitoring agencies, and drug technical data sheets. Physiologically justify why they appear is difficult, if a patient taking ibuprofen suffers a syndrome of Steve Johnson, you may say that it is a very rare adverse reaction, but not why this patient, its idiosyncrasic.